Intimin facilitates colonization by Escherichia coli O157:H7 in adult ruminants.
نویسندگان
چکیده
We compared the magnitude and duration of fecal shedding of wild-type Escherichia coli O157:H7 to that of an isogenic intimin mutant in young adult cattle and sheep. In both ruminant species, wild-type E. coli O157:H7 was shed in greater numbers and for a longer duration than was the intimin mutant.
منابع مشابه
Immunization with H7-HCP-Tir-Intimin Significantly Reduces Colonization and Shedding of Escherichia coli O157:H7 in Goats
Enterohemorrhagic Escherichia coli (EHEC) O157:H7 is the causative agent of hemorrhagic colitis and hemolytic uremic syndrome in humans. However, the bacterium can colonize the intestines of ruminants without causing clinical signs. EHEC O157:H7 needs flagella (H7) and hemorrhagic coli pili (HCP) to adhere to epithelial cells. Then the bacterium uses the translocated intimin receptor (Tir) and ...
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Escherichia coli O157:H7 is an important food-borne pathogen and cause of hemorrhagic colitis and hemolytic uremic syndrome in humans. Cattle are an important reservoir of E. coli O157:H7, in which the organism colonizes the intestinal tract and is shed in the feces. Vaccination of cattle has significant potential as a pre-harvest intervention strategy for E. coli O157:H7; however, basic inform...
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ورودعنوان ژورنال:
- Infection and immunity
دوره 70 5 شماره
صفحات -
تاریخ انتشار 2002